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Systematic review
Meta-analysis: antidepressant exposure during pregnancy is associated with poor neonatal adaptation
  1. Lars Henning Pedersen
  1. Department of Obstetrics and Gynecology, Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark
  1. Correspondence to: Dr Lars Henning Pedersen, Department of Obstetrics and Gynecology, Institute of Clinical Medicine, Aarhus University, Brendstrupgaardsvej 100, Aarhus 8200, Denmark; lhp{at}dadlnet.dk

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Context

Antidepressants are used by 7.6% of pregnant women in the USA.1 Treatment of depression during pregnancy must balance the well-being of the mother with the potential effect on the fetus. Importantly, if prenatal antidepressant exposure causes neonatal symptoms, easy access to neonatal care may be warranted for women treated during pregnancy.

Methods

Grigoriadis and colleagues summarise existing knowledge of the association between prenatal antidepressant exposure and neonatal symptoms. After initial literature searches, they evaluated the detected studies using 19 criteria, calculated a quality rating score (‘high’, ‘moderate’, ‘low’ and ‘very low’) and excluded studies that were considered of ‘very …

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