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Aetiology
Systematic review
Meta-analysis: antidepressant exposure during pregnancy is associated with poor neonatal adaptation
  1. Lars Henning Pedersen
  1. Department of Obstetrics and Gynecology, Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark
  1. Correspondence to: Dr Lars Henning Pedersen, Department of Obstetrics and Gynecology, Institute of Clinical Medicine, Aarhus University, Brendstrupgaardsvej 100, Aarhus 8200, Denmark; lhp{at}dadlnet.dk

https://doi.org/10.1136/eb-2013-101490

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    Commentary on: Grigoriadis S, VonderPorten EH, Mamisashvili L, et al. The effect of prenatal antidepressant exposure on neonatal adaptation: a systematic review and meta-analysis. J Clin Psychiatry 2013;74:e309–20.OpenUrlCrossRefPubMed

    Context

    Antidepressants are used by 7.6% of pregnant women in the USA.1 Treatment of depression during pregnancy must balance the well-being of the mother with the potential effect on the fetus. Importantly, if prenatal antidepressant exposure causes neonatal symptoms, easy access to neonatal care may be warranted for women treated during pregnancy.

    Methods

    Grigoriadis and colleagues summarise existing knowledge of the association between prenatal antidepressant exposure and neonatal symptoms. After initial literature searches, they evaluated the detected studies using 19 criteria, calculated a quality rating score (‘high’, ‘moderate’, ‘low’ and ‘very low’) and excluded studies that were considered of ‘very …

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