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Nausea and vomiting of pregnancy (NVP) affects as many as 50–80% of pregnant women during the first trimester.1 NVP can cause considerable physical and psychological distress, can often be debilitating and sometimes requires hospitalisation. In addition to rehydration and various dietary recommendations, treatment of NVP often requires pharmacological interventions, such as an antihistamine combined with pyridoxine, 5-HT3 antagonist or dopamine antagonist. Despite their widespread use, data regarding the safety of many of these agents in pregnancy are limited, due to the exclusion of pregnant women from clinical …
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