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Cohort study
First trimester fetal size is inversely and modestly associated with cardiovascular risk factors in childhood
  1. Michael R Skilton
  1. Boden Institute of Obesity, Nutrition, Exercise and Eating Disorders, University of Sydney, Sydney, New South Wales, Australia
  1. Correspondence to: Dr Michael R Skilton, Boden Institute of Obesity, Nutrition, Exercise and Eating Disorders, University of Sydney, Sydney, New South Wales, Australia; michael.skilton{at}sydney.edu.au

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Context

Birth weight is inversely associated with risk of cardiovascular disease. The exact timing of the fetal growth disturbances that underpin this association are poorly described. This study examines the association of first trimester fetal growth with cardiovascular risk factors, and risk factor clustering, in children.

Methods

This was a longitudinal cohort study (the Generation R Study) of pregnant women and their offspring in Rotterdam, the Netherlands. Of 8880 women enrolled, this analysis was restricted to 1184 of the offspring with data for first trimester crown-to-rump length, reliable gestational age data and cardiovascular risk measured at 6 years of age (90% range 5.7–6.8 years); 745 had data for clustering of risk factors. First …

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