Context

Outside of a clinical trial setting, most patients with asthma have poorly controlled asthma.1 ,2 Inadequate control of asthma in the community may reflect poor adherence to controller medications; however, the GOAL trial demonstrated that low-to-medium dose inhaled corticosteroids (ICS) were unsuccessful in achieving asthma control in a large proportion of patients with asthma, even with close supervision of care.3 Asthma management guidelines recommend an additional controller medication when asthma control is not achieved with ICS.4 Although the preferred second-choice controller medication is a long-acting inhaled β₂-agonist (LABA), safety concerns regarding LABA use lead many clinicians to add a leukotriene receptor antagonist (LTRA) in its place. This review aimed to compare the efficacy and safety profiles of combinations …