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Systematic review and meta-analysis
Isoflavones hold limited promise for the treatment of menopausal vasomotor symptoms
  1. Katherine M Newton
  1. Group Health Research Institute, Seattle, Washington, USA
  1. Correspondence to : Dr Katherine M Newton, Group Health Research Institute, 1730 Minor Avenue, Suite 1600, Seattle, WA 98101, USA; newton.k{at}ghc.org

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Vasomotor symptoms (VMS) are characterised by feelings of mild to intense warmth in the face, neck and chest, accompanied by minimal to profuse sweating.1 VMS may occur rarely or with great frequency, prevalence varies by ethnicity and they may be present for months to years.2 While many women accept VMS as normal, others find them bothersome, particularly if accompanied by sleep or mood disturbances.

While oestrogen therapy is highly effective in reducing VMS, associated risks reduce enthusiasm regarding their use.3 Professional groups recommend using hormone therapy at the lowest effective dose, for the shortest possible duration.4 Hormone therapy is contraindicated for certain women due to a history of breast cancer or thromboembolism. Others simply …

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