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Therapeutics/Prevention
Randomised controlled trial
Nebulised hypertonic saline does not reduce hospital length of stay in acute bronchiolitis
  1. Todd A Florin
  1. Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
  1. Correspondence to : Dr Todd A Florin, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, ML 2008, Cincinnati, OH 45229, USA; Todd.Florin{at}cchmc.org

https://doi.org/10.1136/ebmed-2015-110168

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    Commentary on: Everard ML, Hind D, Ugonna K, et al. SABRE: a multicenter randomized control trial of nebulised hypertonic saline in infants hospitalised with acute bronchiolitis. Thorax 2014;69:1105–12OpenUrlAbstract/FREE Full Text.

    Context

    Acute bronchiolitis is the most frequent lower respiratory infection in infancy, yet no therapy has shown consistent benefit.1 Although initially promising, there is now conflicting evidence regarding the efficacy of nebulised 3% hypertonic saline (HS). In 2013, a Cochrane meta-analysis concluded that HS may significantly reduce the hospital length of stay among infants hospitalised with mild-to-moderate bronchiolitis and also improve clinical severity scores.2 Other studies suggest that HS has no effect on length of stay.3 ,4

    Methods

    This study was a multicentre, parallel-group, open-label randomised trial comparing 4 mL of nebulised HS administered every 6 h to standard supportive care in infants aged <1 year hospitalised at 1 of 10 hospitals in the …

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    Footnotes

    • Competing interests None.

    • Provenance and peer review Commissioned; internally peer reviewed.