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Randomised controlled trial
Subcutaneous liraglutide reduces weight and improves metabolic control in obese participants
  1. Kyaw Soe,
  2. Kathleen M Dungan
  1. The Ohio State University, Columbus, Ohio, USA
  1. Correspondence to : Dr Kathleen M Dungan, The Ohio State University, 5th floor, McCampbell Hall, 1581 Dodd Dr, Columbus, OH 43210, USA; kathleen.dungan{at}osumc.edu

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Obesity is a major health problem of the 21st century and has been one of the primary contributors to the rising prevalence of type 2 diabetes mellitus (T2DM). A 5–10% loss of total body weight can reduce risk of T2DM onset.1 However, it is challenging to achieve and maintain weight loss that is sufficient for sustained metabolic benefits. Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that was initially developed for treatment of hyperglycaemia in patients with T2DM. It was also noted to have non-glycaemic benefits such as weight loss2 and …

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