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Therapeutics/Prevention
Randomised controlled trial
Early introduction of peanut to infants at high allergic risk can reduce peanut allergy at age 5 years
  1. Scott H Sicherer
  1. Department of Pediatrics, Division of Allergy and Immunology, Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA
  1. Correspondence to : Professor Scott H Sicherer, Mount Sinai Hospital, P.O. Box 1198, 1 Gustave L. Levy Place, New York, NY 10029, USA; scott.sicherer{at}mssm.edu

https://doi.org/10.1136/ebmed-2015-110201

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    Commentary on: Du Toit G, Roberts G, Sayre PH, et al., LEAP Study Team. Randomized trial of peanut consumption in infants at risk for peanut allergy. N Engl J Med 2015;372:803–13OpenUrlCrossRefPubMed.

    Context

    Peanut allergy has tripled among children in the USA; now affecting over 1%.1 The reason for this increase is unknown. Ingestion of a potential allergen should induce oral tolerance. One theory suggests environmental exposure to food, through an impaired skin barrier such as eczema, could provoke allergy if the food is not being ingested.2 The authors of this study previously observed a rate of peanut allergy 10-fold higher among Jewish children in the UK compared with Jewish children in Israel.3 The notable difference is the virtual lack of …

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    Footnotes

    • Competing interests None declared.

    • Provenance and peer review Commissioned; internally peer reviewed.