Article Text

PDF
Randomised controlled trial
Dextromethorphan and quinidine are suitable for off-label short-term treatment of agitation in people with Alzheimer's disease following first-line non-drug approaches
  1. Anne Corbett,
  2. Clive Ballard
  1. Wolfson Centre for Age-Related Diseases, King's College London, London, UK
  1. Correspondence to : Dr Anne Corbett, Wolfson Centre for Age-Related Diseases, King's College London, London SE1 1UL, UK; anne.corbett{at}kcl.ac.uk

Statistics from Altmetric.com

Commentary on: OpenUrlCrossRefPubMed

Context

Agitation is a common and clinically important neuropsychiatric symptom in Alzheimer's disease (AD), conferring risk of distress, caregiver burden, mortality and institutionalisation. Non-drug approaches are best practice for first-line treatment.1 In cases warranting pharmacological treatment, options are limited. Atypical antipsychotics are only justified in cases of severe symptoms due to their lack of efficacy and extensive side effects.2 ,3 Innovation in this field is therefore a high priority. Treatment with dextromethorphan and quinidine has been proposed due to their mechanistic antagonism of nicotinic α3β4 receptor and low-affinity N-methyl-D-aspartate …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.