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Randomised controlled trial
Nasal continuous positive airway pressure outperforms heated high-flow nasal cannula therapy as primary respiratory therapy in preterm infants
  1. Sarah J Kotecha1,
  2. Mallinath Chakraborty2,
  3. Sailesh Kotecha1
  1. 1Cardiff University, Cardiff, UK
  2. 2University Hospital of Wales, Cardiff, UK
  1. Correspondence to: Sarah J Kotecha, Department of Child Health, Cardiff University, Heath Park, Cardiff CF14 4XN, UK; kotechasj{at}cardiff.ac.uk

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High-flow nasal cannula (HFNC) therapy for preterm newborn infants has quickly gained popularity,1 despite few studies evaluating the underlying mechanisms and lack of high-quality studies evaluating its efficacy.2 Our recent systematic review and meta-analysis,3 and the Cochrane review4 suggested that HFNC therapy was comparable in efficacy to continuous positive airway pressure (CPAP) as a primary mode of support in preterm infants at birth, for respiratory distress syndrome (RDS) in preterm …

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