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Randomised controlled trial
Intensive blood pressure lowering provides no additional benefits and results in more adverse events
  1. Else Charlotte Sandset1,2,
  2. Urs Fischer3
  1. 1 Department of Neurology, Oslo University Hospital, Oslo, Norway
  2. 2 Department of Neurology, The George Institute of Public Health, Sydney, Sydney, Australia
  3. 3 Department of Neurology, Inselspital, University Hospital Bern and University of Bern, Bern, Bern, Switzerland
  1. Correspondence to Prof. Dr. Urs Fischer, Department of Neurology, Inselspital, University Hospital Bern and University of Bern; urs.fischer{at}insel.ch

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Commentary on: Qureshi AI, Palesch YY, Barsan WG, et al. Intensive Blood-Pressure Lowering in Patients with Acute Cerebral Hemorrhage. N Engl J Med 2016;375:1033-43.

Context

Elevated blood pressure (BP) in acute intracerebral haemorrhage (ICH) is common and associated with poor outcome. High BP causes an expansion of the intracerebral haematoma, and the ‘Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial’ (INTERACT2) showed that moderate BP lowering <140 mm Hg is safe and likely to reduce death and major disability.1 The results of the INTERACT2 trial changed current guidelines.2 However, it is unclear whether very intensive BP lowering is of any further benefit for patients with ICH.

Methods

The ‘Antihypertensive Treatment of Acute Cerebral Hemorrhage 2’ (ATACH-2) trial was a randomised, multicentre, open-label trial of intensive versus standard BP lowering …

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