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Antenatal corticosteroid administration between 24 hours and 7 days before extremely preterm delivery is associated with the lowest rate of mortality
  1. Colm P Travers,
  2. Waldemar A Carlo
  1. University of Alabama at Birmingham, Birmingham, Alabama, USA
  1. Correspondence to Professor Waldemar A Carlo, University of Alabama at Birmingham, 6 Avenue South Birmingham, AL 35233, USA; wcarlo{at}peds.uab.edu

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Commentary on: Norberg H, Kowalski J, Maršál K, et al. Timing of antenatal corticosteroid administration and survival in extremely preterm infants: a national population-based cohort study. BJOG 2017.  doi: 10.1111/1471-0528.14545. [Epub ahead of print 15 March 2017].

Context

Antenatal corticosteroids (ACS) reduce mortality in preterm infants.1 The association between timing of ACS and outcomes among extremely preterm infants has been sparsely investigated. In a recent large retrospective cohort study, higher odds for severe neonatal morbidity or mortality were seen in infants born at 24–33 weeks gestation with an administration-to-birth interval of ACS <1 or>7 days compared with 1–7 days.2 The objective of this study was to investigate the impact of ACS administration-to-birth interval on survival among extremely preterm infants.

Methods

This population-based cohort study used data collected prospectively …

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