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Evid Based Med 5:74 doi:10.1136/ebm.5.3.74
  • Therapeutics

Rofecoxib caused fewer endoscopic gastroduodenal ulcers than ibuprofen in osteoarthritis

Table 1

Endoscopic gastroduodenal ulcers ≥3 mm with rofecoxib and placebo v ibuprofen for osteoarthritis†

Comparison at 12 wk Event rates RRR (95% CI) NNT (CI)
†Abbreviations defined in glossary; RRR, NNT, and CI calculated using simple proportions with data provided by author.
Rofecoxib, 25 mg/d, v ibuprofen 4% v 25% 85% (68 to 93) 5 (3 to 7)
Rofecoxib, 50 mg/d, v ibuprofen 7% v 25% 73% 52 to 85) 5 (4 to 9)
Placebo v ibuprofen 7% v 25% 72% (49 to 85) 5 (4 to 10)

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