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Therapeutics
Conventional and newer antihypertensive drugs had similar efficacy in elderly people with hypertension

https://doi.org/10.1136/ebm.5.3.85

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    (1999) Lancet 354, 1751. Hansson L, Lindholm LH, Ekbom T, et al,. for the STOP-Hypertension-2 study group.. Randomised trial of old and new antihypertensive drugs in elderly patients: cardiovascular mortality and morbidity the Swedish Trial in Old Patients with Hypertension-2 study.. Nov 20;. :. –6.
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 QUESTION: In elderly people with hypertension, are newer antihypertensive drugs as effective as conventional antihypertensive drugs for reducing cardiovascular events?

    Design

    Randomised {allocation concealed*}†, blinded (outcome assessors),* controlled trial with 4 year follow up.

    Setting

    312 health centres in Sweden.

    Patients

    6614 patients who were 70 to 84 years of age (mean age 76 y, 67% women) and had hypertension (defined as systolic blood pressure ≥180 mm Hg or diastolic blood pressure ≥105 mm Hg or both). Follow up was 100%.

    Intervention

    Patients were allocated to 1 of 3 groups: conventional antihypertensive drugs (atenolol, 50 mg/d; metoprolol, 100 mg/d; pindolol, 5 mg/d; or fixed ratio hydrochlorothiazide, 25 mg/d, and amiloride, 2.5 mg/d) (n=2213); angiotensin converting enzyme (ACE) …

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