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Review: β sitosterols improve urinary symptoms in the short term in men with benign prostatic hyperplasia
  1. Peter S Millard, MD, PhD
  1. Clay Triplehorn, DO Family Practice Residency Program Bangor, Maine, USA

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 QUESTION: In men with benign prostatic hyperplasia (BPH), are β sitosterols effective for improving urinary symptoms?

    Data sources

    Studies were identified by searching Medline (1966 to July 1998), EMBASE/Excerpta Medica (1974 to July 1998), Phytodok, the Cochrane Library, and bibliographies of relevant studies and by contacting authors.

    Study selection

    Studies were selected if they were randomised controlled trials (RCTs) of β sitosterol treatment for ≥30 days in men with symptomatic BPH.

    Data extraction

    2 reviewers independently assessed the quality of study methods and extracted data on patients, intervention, and outcomes (urological symptom scores, urodynamic measures, mean urine flow, residual urine volume, nocturia, and changes in prostate size). Missing or additional data were obtained from authors. Differences were resolved by discussion.

    Main results

    4 double blind, placebo controlled RCTs that involved 519 men (mean age 65 y) met the selection criteria. Trial duration ranged from 4 to 26 weeks, and overall follow up was 92%. 3 RCTs used non-glucosidic β sitosterol, 60 to 195 mg/day, and 1 RCT used 100% β sitosteryl β D glucoside. β sitosterols led to greater improvement in urological symptom scores, nocturia, peak urine flow, mean urine flow, and residual volume than did placebo (table). Groups did not differ for prostate size or adverse effects.

    β sitosterols v placebo for benign prostatic hyperplasia*

    Conclusion

    In men with benign prostatic hyperplasia, β sitosterols lead to short term improvement in urinary symptoms.

    Commentary

    The meta-analysis by Wilt and colleagues is based on 4 small placebo controlled RCTs of purified plant sterol extracts (β sitosterols) derived from the genus Hypoxis (South African star grass), Pinus, or Picea. These agents, which are widely prescribed in Europe, have clinically important short term benefits for urinary flow and obstructive symptoms.

    Saw palmetto, a botanical agent that is biochemically distinct from β sitosterol, is more widely used in the United States and was shown to have similar clinical benefits in a recent systematic review of 18 RCTs by the same authors.1 A recent in vitro study suggests that saw palmetto, but not β sitosterol, may have β 1 adrenergic blocking properties.2

    The challenge for clinicians is to advise their patients about the risks and benefits of these 2 families of phytotherapeutic compounds compared with those of α 1 adrenergic blockers, such as terazosin, and 5 α reductase inhibitors, such as finasteride. 2 studies comparing saw palmetto with finasteride (summarised in the JAMA review1) suggest that their short term effects on symptoms and urinary flow are similar but that saw palmetto causes less erectile dysfunction.

    We still lack essential information about the long term effects of the agents and how to use them alone or in combination. We do know that these plant based derivatives (saw palmetto extract, US$20/mo) are much less expensive than finasteride ($82/mo) or terazosin ($49/mo).

    References

    View Abstract

    Footnotes

    • Source of funding: no external funding.

    • For correspondence: Mr R Mac Donald, General Internal Medicine (111-0), Minneapolis VA/VISN 13 Center for Chronic Diseases Outcomes Research, 1 Veterans Drive, Minneapolis, MN 55417, USA. Fax +1 612 725 1964.

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