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Therapeutics
Lactobacillus GG reduced diarrhoea incidence in children treated with antibiotics

https://doi.org/10.1136/ebm.5.4.113

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    (1999) J Pediatr 135, 564; Vanderhoof JA, Whitney DB, Antonson DL, et al.. Lactobacillus GG in the prevention of antibiotic-associated diarrhea in children.. Nov;. :. –8.
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 QUESTION: In children being treated with antibiotics, does co-administration of Lactobacillus GG (LGG) reduce the incidence of diarrhoea?

    Design

    Randomised (allocation concealed*), blinded (clinicians, patients, and outcome assessors),* placebo controlled trial with 10 day follow up.

    Setting

    Primary care paediatric practice in Rapid City, South Dakota, United States.

    Patients

    202 children between 6 months and 10 years of age who had an acute infection of the upper or lower respiratory tract, urinary tract, soft tissues, or skin and were prescribed a 10 day course of antibiotics. Exclusion criteria were chronic disease, serious acute infection, or diarrhoea at the start of antibiotic administration. 188 children (93%) (median age 4 y, 55% girls) completed the study.

    Intervention

    Children were allocated to LGG …

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    Footnotes

    • Source of funding: ConAgra, Inc.

    • For correspondence: Dr J A Vanderhoof, University Medical Associates, 985160 NE Medical Center, University of Nebraska, Omaha, NE 68198-5160, USA. Fax +1 402 559 2412.

    • A modified version of the abstract also appears in Evidence-Based Nursing.

    • ↵* See glossary.

    • ↵† p Value calculated from data in article.