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  • Review: palliative chemotherapy reduces death and progression at 12 months in advanced or metastatic colorectal cancer

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Therapeutics
Review: palliative chemotherapy reduces death and progression at 12 months in advanced or metastatic colorectal cancer

https://doi.org/10.1136/ebm.6.1.19

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    (2000) Cochrane Database Syst Rev (2). Colorectal Meta-analysis Collaboration.. Palliative chemotherapy for advanced or metastatic colo-rectal cancer.. ;. :CD001545 (latest version 16 Nov 1999). .

    
 
 QUESTION: In patients with locally advanced or meta-static colorectal cancer, what are the benefits and harms of palliative chemotherapy?

    Data sources

    Studies were identified by searching Medline, EMBASE/Excerpta Medica, CancerLit, the Cochrane Controlled Trials Register, CINAHL, HealthSTAR, Science Citation Index, Edina Biosis, NHS Economic Evaluation Database, Index to Scientific and Technical Proceedings, and PASCAL (to October 1998); handsearching conference abstracts; scanning bibliographies of relevant studies; searching sources of unpublished trials; and contacting authors.

    Study selection

    Studies in any language were selected if they were randomised controlled trials (RCTs) that compared palliative chemotherapy with supportive care alone in patients with advanced or metastatic colorectal cancer.

    Data extraction

    The quality of studies was …

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