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Therapeutics
Alendronate increased bone mineral density and decreased vertebral fractures in men with osteoporosis

https://doi.org/10.1136/ebm.6.2.55

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    (2000) N Engl J Med 343, 604. Orwoll E, Ettinger M, Weiss S, et al.. Alendronate for the treatment of osteoporosis in men.. Aug 31;. :. –10.
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 QUESTIONS: In men with osteoporosis, does alendronate prevent or reverse bone loss, and does it decrease vertebral fractures?

    Design

    Randomised {allocation concealed*}†, blinded (patients and outcome assessors),* controlled trial with 2 year follow up.

    Setting

    20 centres in the US and 10 in other countries.

    Patients

    241 men (mean age 63 y) who met either of the following sets of criteria: bone mineral density (BMD) at the femoral neck ≥2 SDs below the mean value in normal young men and a BMD at the lumbar spine ≥1 SD below the mean value in normal young men; or femoral neck BMD ≥1 SD below the mean in normal young men and ≥1 vertebral deformity or a history of an osteoporotic fracture. Exclusion criteria included secondary causes …

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