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Evid Based Med 6:111 doi:10.1136/ebm.6.4.111
  • Therapeutics

Review: ACE inhibitors, calcium antagonists, and more intensive blood pressure lowering strategies reduce cardiovascular events

Antihypertensive drug comparisons in patients with hypertension, diabetes mellitus, coronary artery disease, or renal disease*

Outcomes Comparison Event rates RRR (95% CI) NNT (CI)
Stroke CA v D or β 3.9% v 4.3% 13% (2 to 23) 172 (97 to 1113)
RRI NNH (CI)
*Follow up ranged from 4–5 years. β = β-blocker; CA = calcium antagonist; D = diuretic; CAD = coronary artery disease. Other abbreviations defined in glossary; RRR, RRI, NNT, NNH, and CI calculated from data in article.
CAD CA v D or β 4.9% v 4.3% 12% (0 to 26) Borderline significance

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