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QUESTION: In patients with impaired glucose tolerance, is a lifestyle intervention programme effective for preventing type 2 diabetes mellitus?
Design
Randomised (allocation concealed*), unblinded,* controlled trial with mean follow up of 3.2 years (the Finnish Diabetes Prevention Study).
Setting
5 locations in Finland (Helsinki, Kuopio, Oulu, Tampere, and Turku).
Patients
522 patients between 40 and 65 years of age (mean age 55 y, 67% women) who were overweight (body mass index ≥ 25 kg/m2) and had impaired glucose tolerance (mean plasma glucose level between 7.8 and 11.0 mmol/l 2 h after receiving 75 g of oral glucose on 2 occasions, in patients with plasma glucose levels < 7.8 mmol/l after an overnight fast). Exclusion criteria included diabetes mellitus and advanced chronic disease. Follow up …
Footnotes
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Sources of funding: Finnish Academy; Ministry of Education; Novo Nordisk Foundation; Yrjö Jahnsson Foundation; Finnish Diabetes Research Foundation.
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For correspondence: Professor J Tuomilehto, National Public Health Institute, Department of Epidemiology and Health Promotion, Diabetes and Genetic Epidemiology Unit, Mannerheimintie 166, FIN-00300 Helsinki, Finland. Fax +35 89 4744 8338.