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QUESTION: In patients with non-diabetic renal disease, are antihypertensive regimens with angiotensin-converting enzyme (ACE) inhibitors effective for slowing the progression of disease?
Data sources
Studies were identified by searching Medline (May 1977 to September 1997), scanning abstracts in the proceedings of US and international conferences, scrutinising bibliographies from relevant articles, and contacting investigators for unpublished data.
Study selection
English-language randomised controlled trials were selected if they compared the effectiveness of antihypertensive regimens containing ACE inhibitors (enalapril, captopril, benazepril, cilazapril, and ramipril) with that of antihypertensive regimens not containing ACE inhibitors (control group) in patients with non-diabetic renal disease, and if they had ≥ 1 year of follow up.
Data extraction
Data were extracted on sample size, patient characteristics, key components of the intervention, and outcomes. Main outcomes included end-stage renal disease (ESRD), defined as the initiation of long …