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Evid Based Med 7:57 doi:10.1136/ebm.7.2.57
  • Therapeutics

Review: antidepressants improve headache in patients with chronic headache

Antidepressants v placebo for chronic headache*

Weighted event rates†
Outcome at 4 to 27 weeks Antidepressants Placebo RBI (95% CI) NNT (CI)
*Meta-analyses were done using a random effects model. Abbreviations defined in glossary; RBI, NNT, and CI calculated from data in article.
†Information provided by author.
Overall improvement 65% 33% 100% (60 to 140) 4 (3 to 5)

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