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Evid Based Med 7:110 doi:10.1136/ebm.7.4.110
  • Therapeutics

Review: antiplatelet treatment prevents occlusive vascular events in high risk patients

Antiplatelet v control treatment for serious vascular events (mean 0.7 to 29 mo of treatment)*

Adjusted event rates
High risk category Number of trials Antiplatelet Control RRR (95% CI) NNT (CI)
*Serious vascular events were non-fatal MI, non-fatal stroke, or death from a vascular or unknown cause. MI = myocardial infarction; TIA = transient ischaemic attack. Other abbreviations defined in glossary; RRR, NNT, and CI calculated from data in article.
All trials 195 10.7% 13.2% 19% (16 to 21) 41 (36 to 48)
Previous MI 12 13.5% 17.0% 21% (16 to 26) 28 (22 to 39)
Acute MI 15 10.4% 14.2% 27% (21 to 32) 26 (21 to 35)
Previous stroke or TIA 21 17.8% 21.4% 17% (12 to 21) 28 (22 to 39)
Acute stroke 7 8.2% 9.1% 10% (4.3 to 16) 108 (68 to 261)
Other high risk condition 140 8.0% 10.2% 21% (16 to 26) 46 (36 to 61)

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