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Evid Based Med 2002;7:139 doi:10.1136/ebm.7.5.139
  • Therapeutics

A lifestyle intervention or metformin prevented or delayed the onset of type 2 diabetes in people at risk

(2002) N Engl J Med 346, 393; Diabetes Prevention Program Research Group.. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.. Feb 7;. :. –403.


 
 QUESTION: In overweight people with increased fasting and postload plasma glucose concentrations, does an intensive lifestyle intervention or treatment with metformin plus standard lifestyle recommendations prevent or delay the onset of type 2 diabetes mellitus?

Design

Randomised (allocation concealed*), blinded (clinicians and participants for metformin and placebo),* placebo controlled trial with mean follow up of 2.8 years.

Setting

27 centres in the US.

Participants

3234 participants (mean age 51 y, 68% women) without diabetes who had a body mass index ≥24 (≥22 for Asians) and a plasma glucose concentration of 5.3 to 6.9 mmol/l in the fasting state and 7.8 to 11.0 mmol/l 2 hours after a 75 g oral glucose load. Exclusion criteria included medications known to alter glucose tolerance and illnesses that could seriously reduce life …

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