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Evid Based Med 7:146 doi:10.1136/ebm.7.5.146
  • Therapeutics

Review: β2 agonists are ineffective but increase adverse effects in acute bronchitis without underlying pulmonary disease

β2 agonists v placebo for acute bronchitis without underlying pulmonary disease*

Weighted event rates
Outcomes Patient group β2 agonists Placebo RRI (95% CI) NNH (CI)
ST at 3 to 7 days Children 11% 0% 576% (–14 to 5218) 9 (5 to 100)
Shaking, tremor, or nervousness at 3 to 7 days Adults† 55% 11% 388% (185 to 758) 2.3 (2 to 3)
RRR (CI) NNT (CI)
Cough at > 7 days Adults 64% 71% 14% (–18 to 37) Not significant
Night cough at > 7 days Adults 24% 29% 16% (–33 to 46) Not significant
Standardised mean differences (CI)
*DCSSs = daily cough symptom scores; ST = shaking or tremor. Other abbreviations defined in glossary; RRI, RRR, NNH, NNT, and CI calculated from data in article using random effects.
†Event rates provided by author.
DCSSs at 3 days Children 0.36 (–0.05 to 0.77)
DCSSs at 4 days Adults –0.14 (–0.38 to 0.11)

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