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Therapeutics
A normal calcium, low protein, low salt diet reduced recurrence of renal stones over 5 years

https://doi.org/10.1136/ebm.7.5.152

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    (2002) N Engl J Med 346, 77; Borghi L, Schianchi T, Meschi T, et al.. Comparison of two diets for the prevention of recurrent stones in idiopathic hypercalciuria.. Jan 10;. :. –84.
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 QUESTION: In men with recurrent calcium oxalate stones and hypercalciuria, is a diet containing a normal amount of calcium but reduced amounts of animal protein and salt more effective than a traditional low calcium diet?

    Design

    Randomised (unclear allocation concealment*), blinded (outcome assessors),* controlled trial with 5 years of follow up.

    Setting

    An outpatient department in Parma, Italy.

    Patients

    120 men (mean age 45 y) who had idiopathic hypercalciuria (urinary calcium excretion > 300 mg/d) on an unrestricted diet, recurrent formation of calcium oxalate stones ( ≥ 2 colic episodes with expulsion of stones or radiographic evidence of retained stones), no known condition commonly associated with calcium nephrolithiasis, no previous visit to a stone disease centre, and no current treatment for prevention of recurrent stones. 103 men (86%) completed the study (13 withdrew, 2 were lost …

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    Footnotes

    • Sources of funding: University of Parma; Italian Ministry for Universities and for Scientific and Technological Research.

    • For correspondence: Dr L Borghi, University of Parma, Parma, Italy. loris.borghi{at}unipr.it.

    • ↵* See glossary.