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Therapeutics
Review: β blockers increase fatigue and sexual dysfunction but not depression after myocardial infarction

https://doi.org/10.1136/ebm.8.1.15

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    (2002) JAMA. 288, 351; Ko DT, Hebert PR, Coffey CS, et al. . β. -blocker therapy and symptoms of depression, fatigue, and sexual dysfunction.. ;. :. –7..
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 QUESTION: In patients who have had myocardial infarction, heart failure, or hypertension, do β blockers increase depressive symptoms, fatigue, and sexual dysfunction?

    Data sources

    Studies were identified by searching Medline (1966–2001) with the keywords myocardial infarction, heart failure, or hypertension in combination with the keywords adrenergic β antagonists and trial; and by scanning reference lists.

    Study selection

    English language studies were selected if they were randomised controlled trials with a placebo comparison, were not crossover trials, enrolled ≥100 patients, and had ≥6 months of follow up.

    Data extraction

    Data were extracted on number of patients; presence of heart failure, hypertension, or myocardial infarction; length of follow up; type of β blocker; and patient reported adverse events (ie, depressive symptoms, fatigue, …

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    Footnotes

    • Source of funding: not stated.

    • For correspondence: Dr H M Krumholz, Yale University School of Medicine, New Haven, CT, USA. harlan.krumholz{at}yale.edu

    • Abstract and commentary also published in ACP Journal Club