Article Text
Therapeutics
Losartan was more effective than atenolol for isolated systolic hypertension and left ventricular hypertrophy
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QUESTION: In patients with isolated systolic hypertension (ISH) and left ventricular hypertrophy (LVH), is losartan based therapy more effective than atenolol based therapy?
Design
Randomised {allocation concealed*}†, blinded {patients, clinicians, data collectors, outcome assessors, data analysts, and manuscript writers}†,* controlled trial with mean 4.7 year follow up.
Setting
945 outpatient settings in Europe and the US.
Patients
1326 patients between 55 and 80 years of age (mean age 70 y, 60% women) with ISH (sitting blood pressure [BP] 160–200 mm Hg systolic and <90 mm Hg diastolic after 1–2 wk of placebo) and electrocardiographic signs of LVH. …