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Aetiology
The measles, mumps, and rubella vaccine was not associated with autism in children
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https://doi.org/10.1136/ebm.8.3.93

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    (2002) N Engl J Med 347:1477. Madsen KM, Hvid A, Vestergaard M, et al.. A population-based study of measles, mumps, and rubella vaccination and autism.. ;. :. –82.
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 QUESTION: In children, is the measles, mumps, and rubella (MMR) vaccine associated with autism?

    Design

    Population based cohort study with data obtained by database linkage.

    Setting

    Denmark.

    Participants

    537 303 children (51% boys).

    Assessment of risk factors

    MMR vaccination status at 15 months of age was obtained from the Danish National Board of Health (compiled by general practitioner reports). Data on birth weight, sex, gestational age, family socioeconomic status, and mother’s education were also collected.

    Main outcome measure

    Children’s autism status was obtained from the Danish Psychiatric Central Register; diagnoses of autistic disorder or another autistic spectrum disorder were assigned by specialists in child psychiatry. When a child was diagnosed with both autistic disorder and ≥1 other autistic spectrum disorder, the diagnosis was classified as autistic disorder.

    Main results

    The 537 303 children had follow up …

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