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Therapeutics
Pravastatin lowered coronary disease risk in elderly persons with or at risk of vascular disease

https://doi.org/10.1136/ebm.8.4.107

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    (2002) Lancet 360, 1623. Shepherd J, Blauw GJ, Murphy MB, et al.. Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial.. ;. :. –30.
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 QUESTION: In elderly persons with or at risk of vascular disease, what is the effectiveness and safety of pravastatin?

    Design

    Randomised (allocation concealed*), blinded (clinicians, participants, data collectors, and outcome assessors),* placebo controlled trial with mean follow up of 3.2 years (Prospective Study of Pravastatin in the Elderly at Risk [PROSPER]).

    Setting

    Scotland, Ireland, and the Netherlands.

    Participants

    5804 participants between 70–82 years (mean age 75 y, 52% women) who had a history of vascular disease (coronary, cerebral, or peripheral) or risk factors for vascular disease (eg, smoking, hypertension, or diabetes), a total plasma cholesterol concentration between 4.0 and 9.0 mmol/l, and a triglyceride concentration <6.0 mmol/l. Participants with poor cognitive function (Mini-Mental State Examination score <24) were excluded. Follow up …

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