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Therapeutics
Tamoxifen reduced breast cancer risk but increased risks of thromboembolic events and all cause mortality in women

https://doi.org/10.1136/ebm.8.4.110

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    (2002) Lancet 360, 817. IBIS investigators.. First results from the International Breast Cancer Intervention Study (IBIS-I): a randomised prevention trial.. ;. :. –24.
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 QUESTION: In women with an increased risk of breast cancer, does tamoxifen reduce the risk of breast cancer and what are the associated harms?

    Design

    Randomised (allocation concealed*), blinded {clinicians, patients, data collectors, outcome assessors}†,* placebo controlled trial with median follow up of 50 months.

    Setting

    Europe, Australia, and New Zealand.

    Patients

    7152 women 35–70 years of age (mean age 51 y, 49% postmenopausal) who had an increased risk of breast cancer. Exclusion criteria included previous invasive cancer, previous deep vein thrombosis or pulmonary embolism, anticoagulant use, and pregnancy. Follow up was 99.8%.

    Intervention

    Women were allocated to receive …

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