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  • Review: continuous positive airway pressure therapy improves subjective and objective sleepiness in obstructive sleep apnoea

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Therapeutics
Review: continuous positive airway pressure therapy improves subjective and objective sleepiness in obstructive sleep apnoea

https://doi.org/10.1136/ebm.8.4.112

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    (2003) Arch Intern Med 163, 565. Patel SR, White DP, Malhotra A, et al.. Continuous positive airway pressure therapy for treating sleepiness in a diverse population with obstructive sleep apnea: results of a meta-analysis.. ;. :. –71.
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 QUESTION: In patients with obstructive sleep apnoea (OSA), does continuous positive airway pressure (CPAP) therapy improve subjective and objective measures of sleepiness more than placebo?

    Data sources

    Studies were identified by searching Medline (1966–2001); previous meta-analyses, including the Cochrane database; and bibliographies of retrieved articles; and by contacting experts in the field.

    Study selection

    Studies were selected if they were randomised controlled trials of CPAP therapy in adult patients with OSA for ≥1 week and they evaluated subjective sleepiness using the Epworth Sleepiness Scale (ESS) and objective sleepiness using either the multiple sleep latency (MSLT) or the maintenance of wakefulness test (MWT) score, and had a control arm. Studies that compared CPAP devices with oral appliances and autotitrating devices, and observational studies without a control group were excluded.

    Data extraction

    Data were …

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    Footnotes

    • Sources of funding: National Institutes of Health; Medical Research Council of Canada; American Heart Association.

    • For correspondence: Dr N T Ayas, Vancouver General Hospital, Vancouver, BC, Canada. ayasnajib{at}pol.net