You are here

Article Text

Article menu
Download PDFPDF
Therapeutics
Gabapentin improved sensory and motor symptoms in the restless legs syndrome

https://doi.org/10.1136/ebm.8.4.117

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    (2002) Neurology 59, 1573. Garcia-Borreguero D, Larrosa O, de la Llave Y, et al.. Treatment of restless legs syndrome with gabapentin: a double-blind, cross-over study.. ;. :. –9.
    OpenUrlAbstract/FREE Full Text

    
 
 QUESTION: In patients with restless legs syndrome (RLS), is gabapentin more effective than placebo for improving sensory and motor symptoms?

    Design

    13 week randomised (allocation concealed*), blinded (clinicians and patients),* placebo controlled, crossover trial.

    Setting

    Madrid, Spain.

    Patients

    24 patients who were 33–75 years of age (mean age 55 y, 67% women) and were diagnosed with idiopathic RLS (established by the International RLS Study Group). Patients with ferritin concentrations <20 μg/ml were excluded. 21 patients (88%) completed the study.

    Intervention

    Patients were allocated to sequence 1 (gabapentin followed by placebo) or sequence 2 (placebo followed by gabapentin). Gabapentin was given at an initial dose of 600 mg/day, up to a maximum dose of 2400 mg/day. The sequences lasted 6 weeks with a 1 week washout period, and then patients …

    View Full Text