You are here

  • Home
  • Archive
  • Volume 8, Issue 4
  • White matter changes, creatinine, age, and ankle arm index predicted incident MRI defined infarctions in older adults

Article Text

Article menu
Download PDFPDF
Aetiology
White matter changes, creatinine, age, and ankle arm index predicted incident MRI defined infarctions in older adults

https://doi.org/10.1136/ebm.8.4.121

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    (2002) Stroke 33, 2376. Longstreth WT Jr, Dulberg C, Manolio TA, et al.. Incidence, manifestations, and predictors of brain infarcts defined by serial cranial magnetic resonance imaging in the elderly: the Cardiovascular Health Study.. ;. :. –82.
    OpenUrlAbstract/FREE Full Text

    
 
 QUESTION: In older adults whose baseline magnetic resonance imaging (MRI) scan showed no infarctions, what are predictors of infarctions defined by serial cranial MRI?

    Design

    Cohort study with mean and median follow up of 5 years (range 3.2–7.5 y).

    Setting

    4 communities in North Carolina, California, Maryland, and Pennsylvania, USA.

    Participants

    1433 adults ≥65 years of age with no infarctions shown on baseline MRI scan who were able to give informed consent and to respond to questions without the aid of a surrogate respondent.

    Assessment of risk factors

    Baseline data on blood pressure, ankle arm index, cognitive function, activities of daily living (ADL), instrumental ADL, and depression were collected by questionnaires, physical examination, and laboratory tests.

    Main outcome measure

    Incident infarction defined by follow up serial cranial MRI scan, identified by neuroradiologists blinded to participants' clinical information.

    Main results

    On the follow up MRI scan, 254 participants (18%) had ≥1 …

    View Full Text