Article Text


Morphine sulphate analgesia did not affect diagnostic accuracy in undifferentiated abdominal pain

Statistics from

 QUESTION: In patients with undifferentiated abdominal pain (UAP), does morphine sulphate (MS) analgesia affect physical examination and diagnostic accuracy?


Randomised {allocation concealed}*, blinded {patients, healthcare providers, data collectors, outcome assessors, data analysts}*, controlled trial with intended follow up of 7 days after the study related emergency department (ED) visit.


A tertiary care centre in Boston, Massachusetts, USA.


74 patients who were ≥18 years (median age 39 y, 55% women), had severe abdominal pain of <72 hours’ duration, and were being seen in the ED. Patients were excluded if they were pregnant, hypotensive, or allergic to MS; if early opioid analgesia was clearly indicated; or if emergency interventions precluded study enrolment. Follow up was 100%.


Patients were allocated to receive MS, 1 mg/ml (n=38), or saline placebo (n=36) for a 60 …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.