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Therapeutics
Review: exercise training delays death and hospital admission in chronic heart failure

https://doi.org/10.1136/ebm.9.5.137

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    Piepoli MF, Davos C, Francis DP, et al. Exercise training meta-analysis of trials in patients with chronic heart failure (ExTraMATCH). BMJ 2004;328:189–92.
    OpenUrlAbstract/FREE Full Text

    
 
 Q In patients with chronic heart failure (CHF) resulting from left ventricular systolic dysfunction, does exercise training reduce death or admission to hospital?

    Clinical impact ratings GP/FP/Primary care ★★★★★★☆ IM/Ambulatory care ★★★★★★☆ Cardiology ★★★★★☆☆

    METHODS

    Embedded ImageData sources:

    Medline; Cochrane Reviews database; reference lists; abstracts presented at scientific meetings and published in Circulation, Journal of the American College of Cardiology, or European Heart Journal; and contact with researchers.

    Embedded ImageStudy selection and assessment:

    randomised controlled trials (RCTs) from 1990 on that evaluated exercise training (without any other simultaneous intervention) in patients who had CHF for ⩾3 months (resulting from left ventricular systolic dysfunction). The exercise programme had to last ⩾8 weeks and involve at least both legs. Individual patient data from all RCTs were entered into a master database for analysis.

    Embedded ImageOutcomes:

    death at ⩾3 months and hospital admission.

    MAIN RESULTS

    9 RCTs (8 from Europe) met the selection criteria. Sample size ranged from 27–181 …

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