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Cholesterol lowering with simvastatin reduced stroke in patients with, or at risk of, vascular disease

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 Q Does cholesterol lowering with simvastatin reduce the incidence of stroke in patients with, or at high risk of, vascular disease?

Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ IM/Ambulatory care ★★★★★★☆ Internal medicine ★★★★★★☆ Cardiology ★★★★★★☆ Neurology ★★★★★★☆ Geriatrics ★★★★★☆☆

METHODS

Embedded ImageDesign:

randomised controlled trial (Heart Protection Study).

Embedded ImageAllocation:

{concealed*}.

Embedded ImageBlinding:

blinded {patients, clinicians, and data monitoring committee}.*

Embedded ImageFollow up period:

5 years.

Embedded ImageSetting:

{69 hospitals in the UK}.

Embedded ImagePatients:

20 536 patients (mean age 64 y, 75% men) who had non-fasting total cholesterol concentrations ⩾3.5 mmol/l (135 mg/dl) and a medical history of cerebrovascular disease, coronary disease, other occlusive arterial disease, or diabetes, or were men ⩾65 years of age treated for hypertension. Exclusion criteria: clear indication …

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