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  • Review: calcium supplementation has a small positive effect on bone mineral density but not fractures in postmenopausal women

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Therapeutics
Review: calcium supplementation has a small positive effect on bone mineral density but not fractures in postmenopausal women

https://doi.org/10.1136/ebm.9.6.170

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    Shea B, Wells G, Cranney A, et al. Calcium supplementation on bone loss in postmenopausal women. Cochrane Database Syst Rev 2004;(1):CD004526.

    
 
 Q In postmenopausal women, what is the effect of calcium supplementation on bone mineral density (BMD) and fractures?

    Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ IM/Ambulatory care ★★★★★☆☆ Geriatrics ★★★★★★☆ Rheumatology ★★★★★★☆

    METHODS

    Embedded ImageData sources:

    Cochrane Controlled Trials Register (2001), Medline (January 1966 to April 2001), EMBASE/Excerpta Medica (January 1966 to April 2001), Current Contents (review of the 6 mo prior to April 2001), bibliographies of relevant articles, experts, and proceedings of international meetings.

    Embedded ImageStudy selection and assessment:

    randomised controlled trials (RCTs) that compared calcium supplementation (⩾400 mg/d) with usual calcium intake where both groups received a maintenance dose of vitamin D ⩽400 IU/day and a vitamin D loading dose ⩽300 000 IU; examined women >45 years who were postmenopausal (absence …

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