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Evid Based Med 9:183 doi:10.1136/ebm.9.6.183
  • Therapeutics

Primary tumour excision with a surrounding margin of 3 cm reduced recurrence in melanomas > 2 mm thick

Primary tumour excision with a surrounding margin of 1 cm v 3 cm in high risk malignant melanoma at a median follow up of 60 months*

Outcomes 1 cm margin 3 cm margin RRI (95% CI) NNH (CI)
*Composite outcome  =  tumour recurrence or all cause mortality. Other abbreviations defined in glossary; event rates, RRI, NNH, and CI calculated from data in article.
†Borderline significance (p = 0.05).
Local, in transit, or nodal tumour recurrence 38% 32% 20% (0 to 43) 16 (8 to ∞)†
All cause mortality 32% 31% 6% (−13 to 28) Not significant
Composite outcome 49% 44% 15% (−1 to 30) Not significant

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