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- oestrogen replacement therapy
- coronary disease
- breast neoplasms
- oestrogens
- hip fractures
- hysterectomy
- postmenopause
Q In postmenopausal women with prior hysterectomy, what is the effect of conjugated equine oestrogen (CEE) on major disease rates?
Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ IM/Ambulatory care ★★★★★★☆ Endocrine ★★★★★★☆ Gynaecology ★★★★★☆☆
METHODS
Design:
randomised placebo controlled trial (Women’s Health Initiative [WHI]).
Allocation:
{concealed*}†.
Blinding:
blinded {participants, clinicians, data collectors, and outcome assessors}†.*
Follow up period:
mean 6.8 years.
Setting:
40 US clinical centres.
Participants:
10 739 postmenopausal women aged 50–79 years (mean age 64 y, 75% white) with prior hysterectomy. Exclusion criteria included probable survival <3 years and breast cancer.
Intervention:
CEE, 0.625 mg/day (n = 5310); or matching placebo (n = 5429).
Outcomes:
incidences of coronary heart disease (CHD) (defined as CHD death or non-fatal myocardial infarction), …