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Randomised controlled trial
High-protein and low-glycaemic diets improve dietary compliance and maintenance of weight loss in overweight adults who have lost weight on a low-calorie diet
  1. Peter Clifton
  1. Baker IDI Heart and Diabetes Institute, Adelaide, South Australia, Australia
  1. Correspondence to: Peter Clifton
    Baker IDI Heart and Diabetes Institute, Level 3, 195 North Terrace, Adelaide, SA 5000, Australia; peter.clifton{at}

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Long-term weight maintenance is difficult, and there is very limited and variable evidence about the value of altering macronutrient composition in order to improve weight maintenance for periods of 6 months or longer. A higher protein diet has been shown to be useful in some longer studies,1,,3 but there are no data to support a low-glycaemic index (GI) diet.


A total of 1209 overweight and obese adults (body mass index between 27 and 45) were recruited from eight European countries. Eligible participants were aged between 18 and 65 and had at least one healthy child. They were invited to take part in an 8-week low-calorie diet (3.3–4.2 MJ), and those who achieved at least an 8% weight loss were eligible to participate in a 6-month weight-loss maintenance trial. Of the 938 who took part in the diet, 773 were …

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