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Randomised controlled trial
PREDIMED trial: Mediterranean diet may reduce the risk of type 2 diabetes
  1. Michel de Lorgeril
  1. School of Medicine of the Grenoble University, La Tronche, France
  1. Correspondence to Michel de Lorgeril
    PRETA – TIMC – IMAG, Equipe Coeur & Nutrition, Faculté de Médecine, Domaine de la Merci, Université de Grenoble, 38706 La Tronche, France; michel.delorgeril{at}ujf-grenoble.fr

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Context

The incidence of type 2 diabetes is increasing and has been associated with the Westernisation of dietary habits. The Mediterranean dietary pattern (Med diet) may be a way to reduce the incidence of type 2 diabetes. In a trial, it was shown to reduce the need for antidiabetic drugs in diabetic patients,1 and an epidemiological study suggested a lower incidence of diabetes with increasing adherence to the Med diet.2 However, its role in the prevention of diabetes has not been investigated so far in a randomised trial.

Methods

The Prevención con Dieta Mediterránea (PREDIMED) study is a three-arm randomised trial to assess the effects of two Med diets (supplemented with either olive oil or mixed nuts) versus a low-fat control …

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