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Randomised controlled trial
Randomised trial of radical prostatectomy versus watchful waiting finds reduced risk for death but uncertainty still reigns
  1. John Concato1,2,
  2. Peter Guarino1
  1. 1Cooperative Studies Program, VA Connecticut Healthcare System, West Haven, Connecticut, USA
  2. 2Internal Medicine, Yale University School of Medicine, West Haven, Connecticut, USA
  1. Correspondence to: John Concato
    Clinical Epidemiology Research Program, VA Connecticut Healthcare System, 950 Campbell Avenue, CERC 151B, West Haven, CT 06516, USA; john.concato{at}yale.edu

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Context

Data comparing surgery versus watchful waiting for prostate cancer are important, and the results are also relevant when evaluating whether and when screening for prostate cancer is effective.1 Thus, deciding whether such study results are valid, and how well they generalise, is a prominent challenge in men's health.

Methods

This randomised trial seeks to determine whether mortality from prostate cancer is lower after radical prostatectomy than with primary expectant management. As an ongoing project for more than 20 years, prior major reports appeared in 2002,2 20053 and 2008.4 The …

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