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Randomised controlled trial
Single-tablet double-dose famotidine plus ibuprofen decreases endoscopic upper GI ulcers compared with ibuprofen alone
  1. Kentaro Sugano
  1. Department of Medicine, Jichi Medical University, Shimotsuke, Japan
  1. Correspondence to Kentaro Sugano
    Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke 329-0498, Japan; sugano{at}jichi.ac.jp

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Non-steroidal anti-inflammatory drugs (NSAID) are widely prescribed worldwide. However, NSAID use frequently accompanies gastrointestinal (GI) injury including complications such as bleeding and perforation. Therefore co-therapy with gastroprotective drugs especially for those at risk has been advocated in current guidelines1 in which proton-pump inhibitors (PPI) and misoprostol are recommended to reduce NSAID-induced gastroduodenal ulcers. Another approach is to use cyclooxygenase-2 (COX-2) specific inhibitors.1 The role of histamine-2 receptor antagonists (H2RAs), however, remains uncertain in this regard. The only H2RA that showed …

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