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High-dose acyclovir therapy substantially reduces death and improves neurological outcome from neonatal herpes simplex virus (HSV) infection.1 The effect of time of initiation of therapy on outcomes is not known precisely. Shah and colleagues sought to determine whether delayed acyclovir therapy after hospitalisation was associated with death among neonates with HSV infection.
In this retrospective, multicentre observational study, data were obtained from the Paediatric Health Information System (PHIS), a US national database containing resource-utilisation data during hospitalisation in 41 freestanding, tertiary care children's hospitals from 2003 through 2009. Infants ≤28 days of age with a discharge diagnosis of HSV infection were studied. The primary exposure of interest was early acyclovir administration (given …
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