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Cohort study
Statin use in postmenopausal women is associated with an increased risk of incident diabetes mellitus
  1. Sarah H Wild1,
  2. Christopher D Byrne2,3
  1. 1Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK
  2. 2Nutrition and Metabolism Academic Unit, Faculty of Medicine, University of Southampton, UK
  3. 3University Hospital of Southampton, National Institute for Health Research, Biomedical Research Centre, Southampton, UK
  1. Correspondence to: Christopher D Byrne
    University Hospital Southampton, University of Southampton, Southampton SO166YD, UK; cdtb{at}soton.ac.uk

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Context

The evidence that statins reduce both all-cause and cardiovascular disease mortality when used for both primary and secondary prevention is incontrovertible. However, recent meta-analyses of trials have also shown that statins increase risk of incident diabetes.1 ,2 Culver and colleagues who are from the Women's Health Initiative (WHI) have investigated the association between usage of different statins and incident diabetes in a large cohort of postmenopausal women to assess the balance of risks and benefits of statin treatment in this population.

Methods

The WHI included 161 808 postmenopausal women aged 50–79 years recruited in the USA between 1993 and 1998 in a trial of dietary modification, hormone replacement therapy (HRT) …

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