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Systematic review with meta-analysis
Meta-analysing randomised controlled trials with omega-3 fatty acids in cardiovascular disease
  1. Clemens von Schacky
  1. Department of Preventive Cardiology, University of Munich, Munich, Germany
  1. Correspondence to : Clemens von Schacky
    Department of Preventive Cardiology, University of Munich, Ziemssenstr. 1 Munich 80336, Germany; Clemens.vonschacky{at}

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Commentary on Kwak SM, Myung SK, Lee YJ, et al.; for the Korean Meta-analysis Study Group. Efficacy of omega-3 fatty acid supplements (eicosapentaenoic acid and docosahexaenoic acid) in the secondary prevention of cardiovascular disease: a meta-analysis of randomised, double-blind, placebo-controlled trials. Arch Intern Med 2012;172:686–94.


Systematic reviews and meta-analyses have yielded conflicting results regarding the efficacy of ω-3 fatty acids for preventing cardiovascular events or reducing mortality.1 A meta-analysis of randomised, double-blind, placebo-controlled trials now adds to the literature.


Medline and bibliographies of publications were searched with pertinent keywords, and publications were selected, if trial participants were >18 years of age, had a history of coronary artery disease, used omega-3 fatty acid supplements for >1 year; and if the study design was randomised, double-blind, placebo-controlled, and the trial reported major adverse events (sudden cardiac death, cardiovascular death, all-cause mortality and …

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