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Evid Based Med doi:10.1136/eb-2012-101107
  • Harm
  • Cohort study

Proton pump inhibitors do not induce change in bone mineral density in a long-term observational study

  1. Ryan D Madanick
  1. Division of Gastroenterology & Hepatology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
  1. Correspondence to : Dr Ryan D Madanick
    Division of Gastroenterology & Hepatology, University of North Carolina School of Medicine, CB# 7080, Chapel Hill, NC 27599, USA; madanick{at}med.unc.edu

Commentary on:

Context

Proton pump inhibitors (PPIs) are among the most widely prescribed drug classes worldwide. However recent studies have raised concerns about side effects associated with their long-term use. One major concern related to their use is the development of hip and vertebral fractures, although the relationship remains highly controversial. The mechanism through which PPIs could increase fracture risk is not established, although the speculation is that osteoporosis could develop via PPI-induced alterations in calcium metabolism. This study aimed to evaluate the association between PPI use and decline in bone mineral density (BMD) over time.

Methods

This study used data from the Canadian Multicentre Osteoporosis Study (CaMos), which consisted of a population-based stratified random sample of the …