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Evid Based Med doi:10.1136/eb-2012-101074
  • Harm
  • Randomised controlled trial

It is still an open question whether inhaled glucocorticoid-induced effects may reduce adult height

  1. Ole D Wolthers
  1. Asthma and Allergy Clinic, Childrens’ Clinic Randers, Randers, Denmark
  1. Correspondence to: Dr Ole D Wolthers
    Asthma and Allergy Clinic, Childrens’ Clinic Randers, Dytmaersken 9,3., Randers 8900, Denmark, akk.odws{at}dadlnet.dk

Commentary on: Kelly HW, Sternberg AL, Lescher R, et al.; CAMP Research Group. Effect of inhaled glucocorticoids in childhood on adult height. N Engl J Med 2012;367:904–12

Context

Many randomised double-blind short-term growth studies have been performed in the last two decades showing that inhaled glucocorticoids are associated with a significant risk of dose-related growth suppression in prepubertal children.1–3 Despite having been on the market since the early 1980s for use in children, the potential of inhaled glucocorticoids for suppression of final height, however, has not yet been clarified. This study aimed to answer the question: what happens to adult height in children who present a growth deficit caused by few years’ treatment with inhaled glucocorticoids in childhood?

Methods

This study was an open, observational 8-year follow-up of a principal randomised, double-blind, parallel three-group study, which ran for approximately 4.7 years …

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